You beat me by four minutes. There is a traffic circle just north of Boston that has one exit for state routes 128S/129N and on the other side for 128N/129S that always blew my mind. With state routes, I think that whether they are designated North/South or East/West is determined by their endpoints. I'll have to check on this, probably later today, but when I first moved to the Washington, DC area twenty years ago, stretches of the interstate "Beltway" I-495 would go from being North/South to being East West depending on the polar or azimuth orientation of the highway between successive ramps. They renumbered the highway exits more than a decade ago, but by that time I knew my way around so I've never looked for current North/South or East/West designations on the new signage.