It'll work fine with the proper DLNA software that can transcode the non-compatible file types on the fly. If you use Tversity, it must be v1.7.x.x. If you try 1.8.x.x, it simply doesn't work. I currently use Mezzmo without a hitch. The problem with Media Share, though, is that you can't FF or Rew while watching and I prefer to use my WD Live TV boxes for this job.
Keep in mind, too, that the CPU in the hosting computer will have to be powerful enough to transcode the video on the fly and in real-time or you'll have problems. If it is something like a 1080p BR rip, anything short of an Intel I7 will have a difficult time, if it's DVD quality, any modern multi-core CPU should be up to the task.
The DTV boxes will only accept MPEG-2 format videos, so the transcoding will be necessary for almost any video file out there.